This 2-hour module is specially designed for scientists and researchers related to pharma industries. You will Learn: -
Enzyme Kinetics
•Michaelis-Menten Analysis: Prism allows you to easily fit enzyme kinetic data to the Michaelis-Menten equation. By obtaining parameters such as Vmax and Km, you can characterize enzyme activity and substrate binding.
•Competitive Inhibition: Prism enables you to analyze enzyme kinetic data in the presence of competitive inhibitors. You can calculate inhibition constants (Ki) and assess the impact of inhibitors on enzyme function.
Pharmacology
•Dose-Response Analysis: Prism simplifies the process of fitting and analyzing dose-response curves. You can determine important parameters like EC50, efficacy, and potency, enabling you to evaluate the effectiveness of drugs or compounds.
•Binding Saturation Analysis: Prism provides tools for analyzing binding saturation data, allowing you to determine receptor saturation levels and affinity constants (Kd). This aids in studying ligand-receptor interactions and assessing binding characteristics.
•Schild Competitive Antagonist Analysis: Prism supports Schild analysis, which helps evaluate the competitive nature of antagonists. You can determine pA2 values and assess the potency of competitive antagonists.
•Global Nonlinear Regression: Prism offers robust global nonlinear regression capabilities. This feature allows you to fit complex pharmacological models to your experimental data, enabling more accurate parameter estimation and comprehensive analysis.
Operational Model of Agonist Action:
Prism facilitates analysis based on the operational model of agonism. You can determine key parameters such as affinity, efficacy, and cooperativity of agonists, providing a deeper understanding of agonist-receptor interactions.